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Iranian Researcher Studies Ultrasound-Activated Nanoparticles for Breast Cancer

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Iranian researcher Zeinab Hormozi-Moghaddam explores ultrasound-activated nanoparticles and their potential in experimental breast cancer research.

By News National Editorial Team

An emerging approach combining nanotechnology and ultrasound is attracting scientific interest for its potential applications in breast cancer research. Iranian researcher Zeinab Hormozi-Moghaddam has co-authored studies investigating how specially designed nanoparticles, activated by ultrasound waves, could help trigger the destruction of breast cancer cells.

The research explores a technique known as sonodynamic therapy (SDT), which combines ultrasound energy with substances called sonosensitizers. These substances can interact with ultrasound to produce biological effects that may damage cancer cells.

In a study published on July 15, 2025, in IET Nanobiotechnology, Hormozi-Moghaddam and fellow researchers investigated the effects of curcumin-coated silver nanoparticles combined with ultrasound on MCF-7 breast cancer cells.

The researchers examined whether this combination could promote apoptosis, a natural biological process through which damaged or abnormal cells undergo programmed cell death.

According to the published findings, the combination increased the production of reactive oxygen species (ROS), affected genes associated with cell survival and death, and increased apoptosis in the laboratory-grown breast cancer cells.

The study also reported changes in the expression of important genes, including Bax, Caspase-3 and Bcl-2, which are involved in regulating cell death.

Another study co-authored by Hormozi-Moghaddam, published in Food Bioscience in February 2024, investigated low-intensity ultrasound combined with apigenin-coated gold nanoparticles. It examined how the combination affected apoptosis-related gene expression in MCF-7 breast cancer cells.

Why This Research Matters

Conventional breast cancer treatments include surgery, chemotherapy, radiotherapy and targeted therapies. Researchers continue to investigate complementary approaches that could potentially improve treatment precision while reducing damage to healthy tissues.

Sonodynamic therapy is being explored because ultrasound can deliver energy to targeted areas, while specially designed nanoparticles may help produce local biological effects.

However, these findings remain at the experimental research stage. The studies involved laboratory-grown cancer cells, and further investigations are necessary to establish the technology's safety, effectiveness and suitability for human patients.

Scientific Collaboration and Future Possibilities

The research highlights the growing intersection of nanotechnology, biomedical engineering and cancer science.

Hormozi-Moghaddam's contributions to these studies also demonstrate the role of international scientific research in exploring new approaches to challenging medical conditions.

Although ultrasound-activated nanoparticles are not currently an established replacement for conventional breast cancer treatments, continued research could help scientists better understand their potential role in future cancer therapies.

Important: This technology is experimental and should not be considered a proven or approved breast cancer treatment.